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Other potential dangers include inconsistent ingredient concentrations and formulations that haven't been tested in clinical trials

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Some medical professionals question its legitimacy , primarily because of the lack of peer-reviewed studies that support its efficacy

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Retrieved 16 November 2009

[202] [201] Depending on the protein kinase involved and the residue(s) phosphorylated, phosphorylation can shift transporter function into an efflux-permissive state that causes the reverse transport of cytosolic monoamines into the synaptic cleft, or it can promote transporter internalization, whereby phosphorylated transporters are withdrawn from the plasma membrane and lower total reuptake capacity (i.e., non-competitive reuptake inhibition)